Covid-19 Kawasaki (like) Disease, Genetics, Children and Multi System Inflammatory Syndrome

Posted on May 17, 2020 by Fiona

18th May 2020
Thus far, we have a population of children presenting with serious symptoms now called Multi System Inflammatory Syndrome and thought to be related to the Corona Virus Covid-19 as the cases commenced to show up at the same time as the virus and to my knowledge many or most have been shown to have or had the virus.
I would like to contribute the following.
New York has the largest group of children with this illness and children elsewhere in the world are also presenting with the disease. To date, there are some Asian nations that are not seeing this disease. Why does New York have this large group and why are there Asian nations not seeing this particular set of symptoms?
New York has been struck very severely with many adults affected so we would expect then to see a larger number of children present, as has occurred.
The next question is: what do these children all have in common that is predisposing them to this illness and why are there nations where it is not occurring? (to date).
Did these children all come in contact with a medicine or chemical, not available or in use in these other countries. One has to rule out such possibilities, for instance hand sanitiser suddenly became sought after as a result of the pandemic so we must consider anything new that came into all these children’s lives that wasn’t present before.
If all environmental possibilities have been explored and eliminated, the virus is left and we know the children have tested positive for the virus or the antibodies. Though possibly a handful of the children did not show evidence of the virus past or present. Until it can be clarified for these children, we will need to evaluate how long the antibodies are evident for in this group.
The virus is affecting people in many different ways. Initially it was thought to be detectable via raised temperature but it was soon discovered that a large portion of people weren’t necessarily commencing with a raised temperature and consequently as time passes each day we learn the virus is extremely variable in its effect.
It is clear to me that this virus is interacting with the genome of those it infects and as it is affecting a particular group of adults in severe and unique ways it would suggest that certain children would also have a severe and unique reaction, though fortunately most children do cope well medically.
If we can be certain that this new disease affecting children is directly caused by the virus then an explanation for those Asian nations not experiencing this presentation of symptoms would indicate that certain genetic factors prevent this inflammatory syndrome.
In my work with Rett Syndrome and Autism, I discovered how it was occurring. These are conditions that affect all nations, but there are certain factors determining how.
Most or many Asian nations have remained constant and in their own regions of the planet and have married people from their own lands.
I for instance was born in New Zealand, have parents born in Scotland and have lived in Australia since a little girl. And the majority of Australians have ancestry from far away as well. When we marry different nationalities than ourselves we provoke quite a bit of genetic activity and reshuffling. Those Asian peoples who have remained constant have very little changes and for example good immune systems remain good and strong in these conditions whereas a great deal of genetic change can be a bit of pot luck and we may get an amazing immune system which when worked can be even better or unfortunately for some, every little germ knocks them down.
I could go on but that’s my work with other conditions and this essay is in relation to the problem that we all have with this new virus. But this aspect of difference could well be the reason for those countries not seeing this dreadful condition affecting youngsters.